EDITORIALS
Lung transplant and cystic fibrosis: what’s new from the UK and France?
Correspondence to:
Dr Peadar G Noone, Pulmonary Division, CB# 7020, UNC Chapel Hill, NC 27599-7020, USA; pnoone@med.unc.edu
| The first 150 words of the full text of this article appear below. |
Although the median survival for patients with cystic fibrosis (CF) has improved steadily over the past several decades, many patients go on to develop respiratory failure from progressive lung disease, eventually requiring lung transplantation for extended survival.1 Although many years have elapsed since the first lung transplants were performed for CF, the field is not without controversy.2 The paper recently published by Liou et al is one recent example, suggesting that lung transplant for most children with CF under 18 years of age offers no survival advantage.2 The complex statistical methodology and conclusions have since been challenged and rebutted by several lung transplant experts.3–5 Controversial issues like this often reflect the shortage of randomised controlled trials for many aspects of lung transplant. Although there is much published material related to lung transplant, many protocols are based on retrospective data, or are rather centre or region specific. Although impure because of
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