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Acute renal failure in cystic fibrosis
The outcome of patients with cystic fibrosis has improved considerably over the past years and some of this benefit has been produced by the use of regular intravenous antibiotics, especially aminoglycosides. There has been recently an increase in reports of acute renal failure (ARF) in cystic fibrosis patients and in this month’s Thorax Smyth and colleagues describe a case-control study of ARF in cystic fibrosis. They show that use of intravenous aminoglycoside, particularly gentamicin, is a risk factor for ARF. In the accompanying editorial Goss suggests that the present evidence does not support the call to ban the use of gentamicin in the cystic fibrosis population, but that careful assessment of renal function is now required in these patients who receive intravenous aminoglycosides.
See pages 532
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