EDITORIALS
β2 Adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury
Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California, USA
Correspondence to:
Professor Michael A Matthay, 505 Parnassus Ave, Moffitt Hospital, M-917, University of California, San Francisco, CA 94143-0624, USA; michael.matthay@ucsf.edu
| The first 150 words of the full text of this article appear below. |
Acute lung injury is a clinical syndrome of acute respiratory failure that is responsible for considerable morbidity and mortality in critically ill patients.1 This type of non-cardiogenic pulmonary oedema occurs primarily because of injury to both the endothelial and epithelial barriers of the lung,2 although there are important gaps in our understanding regarding the pathogenesis and resolution of lung injury3 as well as genetic predispositions.4 Major progress in the treatment of acute lung injury has been achieved by a lung protective ventilation strategy that has reduced mortality from 40% to 26%.5 6 Also, a fluid conservative strategy has decreased morbidity by increasing ventilator free days in acute lung injury.7 8
However, no pharmacological therapies have yet been shown to reduce morbidity or mortality in patients with acute lung injury.9 Nevertheless, there is considerable preclinical and clinical work currently in progress to identify potentially effective pharmacological agents for the treatment of acute lung
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