Airwaves
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SKELETAL MUSCLE INFLAMMATION IN COPD
As Sin and Reid point out in their accompanying editorial to the paper by Barreiro and colleagues, skeletal muscle weakness is a serious problem in patients with severe chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality associated with the condition. Both systemic inflammation and oxidative stress have been proposed to play a role in the skeletal muscle dysfunction. In this month’s Thorax, Barreiro and colleagues describe a study in which cytokines were measured by a microarray technique in quadriceps biopsies from COPD patients and controls. The study showed that among the cytokines measured, TNF
levels were actually lower than controls and correlated with quadriceps function (see figure). The authors conclude that there was no evidence of a pro-inflammatory environment in skeletal muscle, even though there was evidence of muscle weakness and oxidative stress.
Mean (SD) values for tumour necrosis factor (TNF) | |||||||||
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