EDITORIALS
Is inflammation good, bad or irrelevant for skeletal muscles in COPD?
1 James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul’s Hospital, The University of British Columbia, Vancouver, BC, Canada
2 Department of Medicine (Respiratory Division), The University of British Columbia, Vancouver, BC, Canada
3 Department of Physical Therapy, The University of British Columbia, Vancouver, BC, Canada
Correspondence to:
Dr D D Sin, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul’s Hospital, Room #368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada; dsin@mrl.ubc.ca
| The first 150 words of the full text of this article appear below. |
Skeletal muscle weakness is a common and serious finding in patients with advanced chronic obstructive pulmonary disease (COPD) and contributes to their morbidity and mortality, increasing the risk of exacerbations, hospitalisations and death by 3–4-fold.1 2 The treatment for muscle dysfunction of COPD is extremely limited, and the multitude of interventions to address poor muscle performance has not been fully explored in these patients. Over the past decade, there has been an explosion of interest and research on this topic. Despite that, the pathophysiological mechanisms linking the lung disease of COPD with skeletal muscle dysfunction remains largely unknown. Identifying a link between lung disease and muscle performance might indeed be a daunting task because of the influence of other comorbid conditions (and medications), previous musculoskeletal injury and the history of physical activity that might influence the current status of skeletal muscle in this condition. There are, however, several observations that are
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