EDITORIALS
RAGE: a biomarker for acute lung injury
1 Royal Brompton Hospital, AICU, London, UK
2 Unit of Critical Care, National Heart and Lung Institute, Imperial College London, London, UK
3 UK and Eire Acute Lung Injury Research Group
4 Northern Ireland Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
5 Respiratory Medicine Research Group, The Queen’s University of Belfast, Belfast, UK
Correspondence to:
Dr Mark Griffiths, Unit of Critical Care, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK; m.griffiths@imperial.ac.uk
| The first 150 words of the full text of this article appear below. |
Acute lung injury (ALI), and its more severe counterpart the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure associated with pulmonary oedema caused by increased permeability of the alveolar–capillary membrane. Many clinical scenarios are recognised as being associated with a high incidence of ALI, including the archetypal direct pulmonary and blood borne insults of pneumonia and severe sepsis, respectively. The internationally accepted diagnostic criteria1 are non-specific to the point of including patients with relatively mild hypoxia and patients with lung pathology that may be different from the classical diffuse alveolar damage.2 ALI is not uncommon but it is challenging to study, partly because the patients are heterogenous in the causes and severity of their illness. Furthermore, patients die with rather than from respiratory failure in the majority of cases.3 These issues partly account for the fact that only one intervention has been shown to affect the survival
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Thorax 2008 63: 1083-1089.[Abstract] [Full Text] [PDF]
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