EDITORIALS
COPD and biomarkers: the search goes on
Correspondence to:
Dr G M Turino, James P Mara Center for Lung Disease, St Luke’s-Roosevelt Hospital, 1000 Tenth Avenue, New York, NY 10019, USA; gmt1@columbia.edu
| The first 150 words of the full text of this article appear below. |
As understanding of cellular and molecular mechanisms underlying disease pathogenesis advances, the opportunities increase to identify specific compounds or molecules which are altered by the disease process or appear de novo. These markers of the pathological process have the potential advantage of indices which are indicative of the existing state or change and can be available non-invasively.1
In this issue of Thorax there is a report of the use of Clara cell secretory protein-16 (CC-16, CC-10 or uteroglobulin) as a biomarker for epithelial cell dysfunction (see page 1058).2 CC-16 is a member of the secretoglobin family of secreted disulfide-bridged dimeric proteins.3 It is secreted by non-ciliated Clara cells which reside in respiratory bronchi and by non-ciliated columnar cells of the large and small airways.4 5 CC-16 also occurs in the epithelial cells of the nose and the urogenital tract of men and women.5 There is evidence, however, that serum
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- Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort
- D A Lomas, E K Silverman, L D Edwards, B E Miller, H O Coxson, R Tal-Singer on behalf of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
Thorax 2008 63: 1058-1063.[Abstract] [Full Text] [PDF]
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