MISCELLANEA
Pulmonary puzzle
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From the question on page 980
The patient underwent a thoracotomy with wedge resection of the right upper lobe of the lung and pathological examination of a specimen showed the presence of malignancy. Lobectomy of the right upper lobe was performed. Microscopic examination revealed sarcomatous tumour cells with dyscohesive pleomorphic nuclei and prominent infiltration (fig 1A). Upon immunochemical analysis the tumour cells were positive for cytokeratin and vimentin (fig 1B and C). The tumour was compatible with a giant cell carcinoma. Thyroid transcription factor-1 was measured to confirm the primary lung origin.
Figure 1 (A) Sarcomatous tumour cells showing dyscohesive pleomorphic nuclei and prominent nucleoli in diffuse infiltration with extensive necrosis (H&E stain, 400x). Tumour cells stained positively for (B) cytokeratin and (C) vimentin. (D) CT scan of the abdomen demonstrating nodule target lesion (arrow) over the right lower abdomen and intestinal dilatation, which was consistent | |||||||||
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Thorax 2008 63: 980.[Extract] [Full Text] [PDF]
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