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Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors
Specialist Registrar in Respiratory Medicine; Helen.Stone@uhb.nhs.uk
| The first 150 words of the full text of this article appear below. |
Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. Hatakeyama S, Sugaya N, Ito M, et al. JAMA 2007;297:1435–42.
Oseltamivir is a neuraminidase inhibitor effective in the treatment of influenza. In this Japanese study, the sensitivity of influenza B virus to neuraminidase inhibitors was assessed in 74 children before and after treatment with oseltamivir, and in a further 348 untreated patients, 66 of whom were adults.
They found that one patient treated with oseltamivir had a variant of influenza B virus with reduced neuraminidase inhibitor sensitivity. Among the untreated group, seven (1.7%) had variants with reduced sensitivity, due to a number of different mutations. Three of these were thought to have been contracted from close contact with siblings carrying variants of influenza B with the same mutation and the remainder contracted within the community. This is in contrast to the influenza A
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