EDITORIAL
Biomarkers in COPD
Biomarkers in COPD: time for a deep breath
Correspondence to:
Correspondence to:
Professor R A Stockley
Department of Medicine, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK; r.a.stockley@bham.ac.uk
Biomarkers need to fulfil several distinct requirements before they can be considered a valid indicator of chronic diseases such as COPD
| The first 150 words of the full text of this article appear below. |
Chronic obstructive pulmonary disease (COPD) has become recognised as a priority area for management of healthcare resources and development of new therapeutic strategies. This is based largely on economic burden and the excessive morbidity and mortality associated with the condition. The result has been a profusion of publications in recent years, many of which start with the observations that "COPD is currently the fifth and by the year 2020 will become the third or fourth leading cause of morbidity and mortality worldwide".
More recently, the COPD literature has entered a second phase. This has arisen from the appreciation that COPD is more than a respiratory inflammatory condition and is associated with manifestations outside the lung. This has led to the concept that COPD is a systemic disease and has resulted in a rapid increase in papers exploring this aspect. Initial studies were primarily based on the association
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