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Thorax 2007;62:561
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AIRWAVES

Wisia Wedzicha, Editor-in-chief

The first 150 words of the full text of this article appear below.


MESOTHELIN IN PLEURAL EFFUSIONS
As Lee points out in his accompanying editorial to the paper by Creaney and colleagues, 150 000 patients develop a pleural effusion in the UK each year and the differential diagnosis poses a challenge because over 50 disorders need to be considered. Serum soluble mesothelin related protein, or "mesothelin", has been shown to be a specific, but moderately sensitive, marker of the presence of mesothelioma. Creaney and colleagues show that measurements of mesothelin in pleural and/or peritoneal effusions can be useful in the differential diagnosis of mesothelioma in patients presenting with effusions (see figure). Lee concludes his editorial by pointing out that mesothelin is a useful marker for epitheloid mesothelioma, but not for other histological types of mesothelioma and further markers need to be developed to increase the diagnostic efficiency.
See p 561 and 569


Figure 1
Mesothelin concentrations in pleural effusions of patients, defined as transudate or exudate in nature and . . . [Full text of this article]


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