EDITORIAL
Pleural fluid test for mesothelioma
Hunting for a pleural fluid test for mesothelioma: is soluble mesothelin the answer?
Correspondence to:
Correspondence to:
Dr Y C Gary Lee
Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford OX3 7LJ, UK; ycgarylee@hotmail.com
| The first 150 words of the full text of this article appear below. |
An estimated 150 000 patients develop a pleural effusion each year in the UK. Establishing the aetiology of pleural effusions can be challenging as they can be associated with over 50 systemic or pulmonary disorders.1 Exudative pleural fluids arise from plasma extravasation and contain proteins and cells from the systemic circulation, as well as those released locally from the pleura. This milieu of cellular products potentially holds vital clues that can unveil the underlying cause of the effusion. Decoding these clues has been a long and slow journey,2 and only in recent years have several disease-specific pleural fluid markers been incorporated into clinical practice (eg, adenosine deaminase for tuberculous pleuritis3 and brain natriuretic peptide for effusions from cardiac failure).
It is logical that diagnostic clues for mesothelioma, a primary pleural malignancy, would rest within the pleural fluid. The incidence of mesothelioma is rising significantly in
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This article has been cited by other articles:
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Creaney, J, Musk, B, De Klerk, N, Robinson, B W
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