EDITORIAL
Acute renal failure in CF
Acute renal failure in people with cystic fibrosis
Correspondence to:
Correspondence to:
Dr Kevin W Southern
Institute of Child Health, University of Liverpool, Royal Liverpool Children’s Hospital, Liverpool L12 2AP, UK; kwsouth@liv.ac.uk
Time to reflect on antibiotic strategies for CF lung infection
| The first 150 words of the full text of this article appear below. |
The putative gene in cystic fibrosis (CF) encodes a protein, cystic fibrosis transmembrane conductance regulator (CFTR), which has an important role in transepithelial salt transport.1 The major organ affected in CF is the lung, with remorseless and intense chronic airway infection resulting from disabled clearance of dehydrated airway surface liquid.2 Airway inflammation leading to end stage lung damage is associated with respiratory morbidity and early death. The outlook for people with CF has improved considerably with a proactive approach to treatment of airway infection as one of the cornerstones of its management. Recent data from the US CF registry suggest a continuing improvement in median predicted survival to over 35 years (http://www.cff.org/research/2006NACFC/Plenary III). With an improving outlook, perspectives have changed and expectations of people with CF and their carers have broadened. A survey of acute renal failure (ARF) in patients with CF
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Thorax 2007 62: 541-545.[Abstract] [Full Text] [PDF]
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