EDITORIAL
Systemic inflammation and progression of COPD
Systemic inflammation and progression of COPD
Correspondence to:
Correspondence to:
Professor Jørgen Vestbo
North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK; Jorgen.vestbo@manchester.ac.uk
The role of C-reactive protein
| The first 150 words of the full text of this article appear below. |
C-reactive protein (CRP) is considered one of the key markers of systemic inflammation in chronic obstructive pulmonary disease (COPD) and currently receives a lot of attention. In their systematic review of systemic inflammation in COPD, Gan et al showed that CRP was associated with the level of forced expiratory volume in 1 s (FEV1) in the five studies included in the review,1 and two recent studies using fairly large populations of well-characterised patients with COPD have shown a strong association between increased CRP levels and prognosis.2,3 Sin and Man have previously shown that raised levels of CRP were associated with cardiac injury in COPD4 but, in the two recent studies, the association between CRP and mortality was not merely driven by an associated risk of cardiovascular deaths.2,3
In this issue of Thorax (see p 515) Fogarty et al examine the association
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