airwaves
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We now know from the recent TORCH data that long acting β2 agonists, inhaled corticosteroids and the combination of these treatments all reduce exacerbations in patients with COPD. However, the relative anti-inflammatory activity of these different treatments has not been fully evaluated. In this month’s Thorax, Bourbeau and colleagues report on a study comparing the effect of the inhaled salmeterol/fluticasone (SFC) combination with inhaled fluticasone (FP) and placebo on airway inflammation. SFC reduced airway CD8+ cells compared with placebo, but this effect was not seen with FP alone. CD68+ macrophages were also reduced by SFC but not FP (see fig). Airway neutrophils and eosinophils were not affected. As Barnes points out in his accompanying editorial to this paper, the fact that a combination of long-acting β2 agonist and inhaled corticosteroid can reduce airway inflammation should encourage those developing new anti-inflammatory treatments for COPD.
See pages 927 and 938
Gosker
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