EDITORIAL
Coeliac disease and risk of tuberculosis
Coeliac disease and risk of tuberculosis: a population-based cohort study
1 Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
2 Division of Epidemiology and Public Health, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, UK
3 School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
Correspondence to:
Correspondence to:
Dr D S Sanders
Royal Hallamshire Hospital, Glossop Road, Room P39, P Floor, Sheffield S10 2JF, Sheffield, UK; david.sanders@sth.nhs.uk
Are patients with coeliac disease at higher risk of tuberculosis?
| The first 150 words of the full text of this article appear below. |
On the basis of screening studies on healthy volunteers, coeliac disease is now recognised to affect 1% of the population.1 The current optimal serological testing for coeliac disease may be immunoglobin (Ig)A endomysial, IgA tissue transglutaminase or a combination of the two, with a positive predictive value in excess of 95% provided IgA deficiency is excluded. Patients with positive serology then require an endoscopic duodenal biopsy to confirm the presence of villous atrophy and thus a firm diagnosis of coeliac disease. A link between coeliac disease and tuberculosis was first suggested as far back as 1952, but there has been a paucity of data exploring this relationship other than case reports and case series.2 The initial focus was on gastrointestinal tuberculosis being one of the differential diagnoses for villous atrophy of the small bowel. However, in 1988 a report from Birmingham, UK, suggested that
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