EDITORIAL
Neutrophilic inflammation in childhood asthma
Neutrophil airway inflammation in childhood asthma
Department of Child Health, University of Aberdeen, Royal Aberdeen Children’s Hospital, Aberdeen AB25 2ZG, UK
Correspondence to:
Correspondence to:
Professor P J Helms
Department of Child Health, University of Aberdeen, Royal Aberdeen Children’s Hospital, Aberdeen AB25 2ZG, UK; p.j.helms@abdn.ac.uk
A novel and inviting therapeutic target?
Keywords: asthma; children; cough; neutrophilic inflammation
| The first 150 words of the full text of this article appear below. |
Although asthma has its highest prevalence in childhood, it is generally less severe than in adolescents and adults.1 Whether the high population prevalence is because symptoms are more noticed by parents or whether the more physically active lifestyle and natural inquisitiveness of children, particularly young children, unmasks bronchial hyperresponsiveness and related symptoms remains elusive to investigation. Whatever the explanation, the population prevalence of asthma and associated symptoms including wheeze and cough remains high, although with recent evidence of stabilisation or even a decline in those countries (including the UK) at the top of national prevalence "league tables".1–4
The investigation of underlying mechanisms is challenging in children because of ethical considerations and the limited applicability of invasive procedures such as bronchoscopy, bronchoalveolar lavage (BAL), and bronchial biopsy. In this context, the report by Li et al in the present issue of Thorax5 using the sputum induction
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Thorax 2006 61: 739.[Extract] [Full Text] [PDF]
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