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Airwaves

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COMBINATION THERAPIES FOR COPD
As Casaburi points out in his accompanying editorial to the paper by Peters and colleagues, COPD is now recognised as distinctly not a disease of irreversible airflow obstruction. A number of pharmacological and non-pharmacological interventions have shown reduction of dyspnoea and improvement of exercise capacity, but we have little information on the additive effects of these therapies and, indeed, this is how they will be used in practice. In this issue of Thorax Peters and colleagues show, for the first time, additive effects on dyspnoea and exercise capacity of bronchodilator therapy and supplemental oxygen in normoxic COPD patients. Endurance time increased by 16% with bronchodilators compared with placebo, by 28% with oxygen alone, and by 40% with the combination of bronchodilator and oxygen compared with the endurance time achieved on room air and placebo. The paper also describes some interesting insights into the mechanisms of these improvements and sets the . . . [Full text of this article]

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Combination therapy for exercise intolerance in COPD

R Casaburi
Thorax 2006 61: 551-552. [Extract] [Full Text] [PDF]