EDITORIAL
Combination therapy for exercise intolerance in COPD
Combination therapy for exercise intolerance in COPD
Correspondence to:
Correspondence to:
Dr R Casaburi
Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W Carson Street, Building J4, Torrance, CA 90502, USA; casaburi@ucla.edu
New combined approaches to reduce dynamic hyperinflation improve exercise intolerance in patients with COPD
Keywords: chronic obstructive pulmonary disease; bronchodilators; oxygen; exercise; dyspnoea; lung hyperinflation
| The first 150 words of the full text of this article appear below. |
Chronic obstructive pulmonary disease (COPD) is a miserable disease; exercise intolerance is one of its most troubling symptoms. Moreover, it has recently been discovered that poor exercise tolerance is highly predictive of poor survival. Those who care for these patients are therefore highly motivated to seek ways to ameliorate exercise intolerance. In recent years progress has come from what, at first glance, would seem to be an unlikely quarter. Although research expenditures for this disease are heavily weighted towards cell and molecular biology pursuits, physiological research (considered "old fashioned" in some quarters) has provided solid insights into rational treatment for exercise intolerance.
A key insight is that dynamic hyperinflation is a major mechanism limiting exercise tolerance in patients with COPD. This occurs when the increased metabolic requirements of exercise demand higher levels of pulmonary ventilation. This, in turn, requires that both tidal volume
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Thorax 2006 61: 551.[Extract] [Full Text] [PDF]
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