EDITORIAL
Post-infectious bronchiolitis obliterans in children
Insights into post-infectious bronchiolitis obliterans in children
Department of Pediatric Pulmonology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Correspondence to:
Correspondence to:
Dr L L Fan
Pulmonary Medicine Service, Texas Children’s Hospital, 6621 Fannin, CC1040.00, Houston, TX 77030, USA; llfan@texaschildrenshospital.org
New information contributing to our understanding of risk factors predisposing to bronchiolitis obliterans in children
Keywords: adenovirus infections; lung function tests; respiratory insufficiency; bronchiolitis obliterans; mechanical ventilation; infants
| The first 150 words of the full text of this article appear below. |
Bronchiolitis obliterans (BO) is a rare form of chronic obstructive lung disease that follows an insult to the lower respiratory tract.1 It is characterised by inflammation and fibrosis of the terminal and respiratory bronchioles that lead to narrowing and/or complete obliteration of the airway lumen. Pathologically, two forms of BO are recognised, and these may be part of a continuum. Proliferative bronchiolitis is characterised by intraluminal exudates, whereas constrictive bronchiolitis is characterised by alterations in the walls of the bronchioles ranging from inflammation to fibrosis and, ultimately, to complete obliteration of the lumen.2 The histological findings of constrictive bronchiolitis are a common end point for many disorders that are associated with airway epithelial injury including allograft recipients (lung, heart-lung, and bone marrow), previous lower respiratory tract infection (adenovirus,3–6 influenza,7 parainfluenza, measles, respiratory syncytial virus,8 or Mycoplamsa pneumoniae9–11), collagen vascular disease (especially rheumatoid arthritis and
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Thorax 2006 61: 459.[Extract] [Full Text] [PDF]
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