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Non-invasive ventilation improves survival in patients with motor neuron disease
SHO, Kettering General Hospital, UK; avance@doctors.net.uk
| The first 150 words of the full text of this article appear below. |
Bourke SC, Tomlinson M, Williams TL, et al. Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial. Lancet Neurol 2006;5:140–7[CrossRef][Medline]
This randomised controlled trial allocated patients with amyotrophic lateral sclerosis to either standard care (n = 19) or non-invasive ventilation (NIV, n = 22). Patients were randomised when they developed orthopnoea with a maximum inspiratory pressure of <60% or symptomatic daytime hypercapnia. They were assessed with the SF-36 and sleep apnoea quality of life index (SAQLI) scores. The authors found that quality of life scores were maintained at 75% above baseline for longer in the patients randomised to NIV (192 v 46 days, p = 0.0013). Furthermore, in the patients with good bulbar function there was a median survival benefit of 205 days (p = 0.006). The subgroup with poor bulbar function
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