EDITORIAL
EGFR expression in NSCLC
Is EGFR expression important in non-small cell lung cancer?
Correspondence to:
Correspondence to:
Dr S M Lee
Meyerstein Institute of Oncology, Middlesex/UCLH Hospitals, Mortimer Street, London W1T 3AA, UK; smlee@ucl.ac.uk
There are still many unanswered questions on the use of EGFR treatment in NSCLC
Keywords: epidermal growth factor receptor; lung cancer; overexpression; survival
| The first 150 words of the full text of this article appear below. |
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is frequently overexpressed in non-small cell lung cancer (NSCLC). These receptors play an important role in tumour cell survival and activated phosphorylated EGFR results in the phosphorylation of downstream proteins that cause cell proliferation, invasion, metastasis, and inhibition of apoptosis. Expression appears to be dependent on histological subtypes, most frequently expressed in squamous cell carcinoma but also frequently expressed in adenocarcinomas and large cell carcinomas.1 Not surprisingly, there are many published reports attempting to correlate the relationship between EGFR protein overexpression and survival. However, the data regarding the prognostic role of EGFR expression are inconsistent and confusing, with some reports indicating that EGFR is associated with poor survival while no prognostic association was seen in other reports.
In this issue of Thorax Nakamura et al carried out a meta-analysis of 18 studies (including nearly 3000 patients), reviewing
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