EDITORIAL
Smoking and COPD
"Susceptible" smokers?
Correspondence to:
Correspondence to:
Dr N R Anthonisen
University of Manitoba, Respiratory Hospital, Winnipeg, Canada R3A 1R8; nanthonisen@exchange.hsc.mb.ca
Many smokers may be "susceptible" to COPD if they live long enough
Keywords: chronic obstructive pulmonary disease; smoking; prognosis
| The first 150 words of the full text of this article appear below. |
In this issue of Thorax Lokke et al report the incidence of COPD in the Copenhagen City Heart Study.1 They were able to do so because they followed a large cohort of representative citizens of Copenhagen for 25 years with spirometric tests, far longer than any previous such study. Non-asthmatics aged 30–60 years with normal initial spirometric parameters and good smoking histories were studied. About 2500 of them underwent spirometric tests at least twice (25 years apart), and vital status was ascertained in another 5500 who did not undergo comparable spirometric measurements. COPD was assessed in terms of the current standards for spirometry2 staged according to GOLD.
More than 24% of the continuous smokers who underwent spirometric tests had COPD (defined as FEV1<80% of predicted, FEV1/FVC <70%) after 25 years, in stark contrast to never smokers in whom COPD occurred in <5%. Those who stopped
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Thorax 2006 61: 923.[Extract] [Full Text] [PDF]
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