Airwaves
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There has been increasing interest in the anti-inflammatory effects of macrolide antibiotics and they have now been studied in a number of conditions. A large trial of the macrolide azithromycin taken over 6 months showed benefit in adult patients with cystic fibrosis (CF) colonised with Pseudomonas aeruginosa, but it is not clear if macrolides are beneficial in younger CF patients. In this issue of Thorax, Clement and colleagues describe a randomised controlled trial of azithromycin given for 3 days per week to CF patients (age 6–21 years) and followed for 12 months. The authors report that azithromycin reduced the number of exacerbations, the time to the first exacerbation, and the number of additional courses of antibiotics, regardless of whether or not they were infected with P aeruginosa. This trial shows that the beneficial effect of azithromycin can be observed at an earlier stage of lung disease and
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