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Complete response to erlotinib treatment in brain metastases from recurrent NSCLC

C S L Lai¹, C Boshoff¹, M Falzon², S M Lee²

¹ Wolfson Institute for Biomedical Research, University College London, London, UK
² University College Hospitals Trust, London, UK

Correspondence to:
Correspondence to:
Professor C Boshoff
Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK; c.boshoff@ucl.ac.uk

Keywords: non-small cell lung cancer; erlotinib; brain metastases

The first 150 words of the full text of this article appear below.

We report a case of a 55 year old Chinese female never smoker who presented with a 6 month history of cough in October 2002. In November 2002 she underwent a right middle lobectomy for adenocarcinoma. In June 2003 a CT scan showed recurrences in the mediastinum, pleura, and ribs. In January 2004 she completed six cycles of treatment with gemcitabine and carboplatin and the CT scan following treatment demonstrated a partial response. In June 2004 she developed breathlessness, unsteadiness, dizziness, and weakness involving the right upper limb. A CT scan showed disease recurrence in the chest with multiple lesions in her right lung and precarinal nodes and brain metastases. She received second line therapy with docetaxel and whole brain radiotherapy (20 Gy in five fractions) for brain metastases in July 2004. However, chemotherapy was suspended after two cycles because of life threatening sepsis. A CT scan performed after chemotherapy . . . [Full text of this article]

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