LUNG ALERT
The public health burden of acute lung injury
Research Registrar, Guy’s & St Thomas’ NHS Foundation Trust, London, UK; luigicamporota@yahoo.co.uk
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Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005;353:1685–93
The public health burden of acute lung injury (ALI/ARDS) in terms of morbidity, mortality, length of hospitalisation, and need for rehabilitation is poorly appreciated. This study reports the results of a prospective, population based, cohort study conducted in 21 hospitals in and around King County, Washington, USA to determine the incidence and mortality associated with ALI/ARDS. Between April 1999 and July 2000, 4251 adults requiring mechanical ventilation for more than 24 hours were screened. Of the 1687 patients with acute hypoxaemic respiratory failure, 1113 had ALI, 828 of whom (74%) had ARDS. The crude incidence of ALI/ARDS was 78.9/58.7 cases per 100 000 person-years, respectively, giving age adjusted national estimates of 86.2/64 cases per 100 000. The in-hospital mortality was 38.5% for ALI and 41.1%
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