Airwaves
| The first 150 words of the full text of this article appear below. |
More effective treatment of COPD exacerbations is an important goal of COPD therapy. A number of guidelines have suggested that intravenous aminophylline can be used to treat COPD exacerbations when the response to usual treatment is inadequate. However, the evidence for this option is weak and the few previous trials of aminophylline at exacerbation have been small and generally underpowered for relevant outcomes. In this month’s Thorax, Duffy and colleagues report the first adequately powered randomised trial of intravenous aminophylline in 80 patients admitted to hospital with COPD exacerbations, and the study is discussed in the accompanying editorial by Town. The study found that the addition of intravenous aminophylline to nebulised bronchodilators and oral corticosteroids in non-acidotic exacerbations produced small improvements in acid-base balance, but there was no effect on the subsequent clinical course. There were no benefits on the severity of breathlessness or length of hospital stay between
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Articles
- Aminophylline for COPD exacerbations? Not usually
- G I Town
Thorax 2005 60: 709.[Extract] [Full Text] [PDF]
- When should a long acting ß agonist be added to an inhaled corticosteroid?
- A E Tattersfield
Thorax 2005 60: 710.[Extract] [Full Text] [PDF]
- Glucose, bronchial secretions and MRSA
- J S Brown
Thorax 2005 60: 711-712.[Extract] [Full Text] [PDF]
- Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma
- M Masoli, M Weatherall, S Holt, and R Beasley
Thorax 2005 60: 730-734.[Abstract] [Full Text] [PDF]
- Glucose in bronchial aspirates increases the risk of respiratory MRSA in intubated patients
- B J Philips, J Redman, A Brennan, D Wood, R Holliman, D Baines, and E H Baker
Thorax 2005 60: 761-764.[Abstract] [Full Text] [PDF]
- Intravenous aminophylline in patients admitted to hospital with non-acidotic exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial
- N Duffy, P Walker, F Diamantea, P M A Calverley, and L Davies
Thorax 2005 60: 713-717.[Abstract] [Full Text] [PDF]
- Patterns of dynamic hyperinflation during exercise and recovery in patients with severe chronic obstructive pulmonary disease
- I Vogiatzis, O Georgiadou, S Golemati, A Aliverti, E Kosmas, E Kastanakis, N Geladas, A Koutsoukou, S Nanas, S Zakynthinos, and Ch Roussos
Thorax 2005 60: 723-729.[Abstract] [Full Text] [PDF]
- Mechanisms of improvement of respiratory failure in patients with restrictive thoracic disease treated with non-invasive ventilation
- A H Nickol, N Hart, N S Hopkinson, J Moxham, A Simonds, and M I Polkey
Thorax 2005 60: 754-760.[Abstract] [Full Text] [PDF]
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
