© 2005 BMJ Publishing Group Ltd & British Thoracic Society
EDITORIAL
Lung repair
Circulating endothelial progenitor cells in pulmonary inflammation
Correspondence to:
Correspondence to:
Dr C M Doerschuk
Case Western Reserve University, Room RBC 787, 11100 Euclid Avenue, Cleveland, OH 44106, USA; cmd22@case.edu
Do endothelial progenitor cells contribute to lung repair and, if so, how?
Keywords: endothelial progenitor cells; inflammation; lung repair
| The first 150 words of the full text of this article appear below. |
Understanding how circulating stem cells released from the haematopoietic compartment accumulate and differentiate into the parenchymal cells of organs has become an exciting, thought provoking, and intriguing forefront of medical science. Many investigators have begun to address the ability of various populations of stem cells to aid in the repair of nearly every organ including the lungs,1–19 either through recruitment and differentiation into parenchymal cells or through facilitating proliferation and differentiation of cells already present to mediate the repair. Numerous questions remain about if and how stem cells can facilitate organ repair.
The studies presented by Yamada and colleagues1 in this issue of Thorax address an important aspect about endothelial progenitor cells (EPC) in lung repair. They show that patients with pneumonia confined to one lobe and no other illnesses have circulating EPC in their blood within the first day of illness, and that this number is decreased
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Thorax 2005 60: 357a.[Extract] [Full Text] [PDF]
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