EDITORIAL

Genetic association studies

Genetic association studies in Thorax

I P Hall, J D Blakey

Division of Therapeutics and Molecular Medicine, Queen’s Medical Centre, University Hospital, Nottingham, UK

Correspondence to:
Correspondence to:
Professor I P Hall
Division of Therapeutics and Molecular Medicine, D Floor, South Block, Queen’s Medical Centre, University Hospital, Nottingham NG7 2UH, UK; ian.hall@nottingham.ac.uk

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A guide to assessing the validity of genetic association studies in respiratory disease

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Keywords: genetic association studies; respiratory disease; case-control; single nucleotide polymorphisms; multiple testing; power

The first 150 words of the full text of this article appear below.

Increasing knowledge regarding the extent of genetic variation in the human genome has led to an explosion of interest in performing genetic association studies in complex diseases. Well designed studies have the potential to provide functionally relevant data on the pathophysiology of disease initiation and severity.¹ Unfortunately, this field has acquired a bad reputation over recent years because of problems with poor design and variable replication of findings.^2,3 Because such studies are relatively easy to undertake when one has access to a population of patients with disease, the number of such studies has increased markedly: Thorax now receives, on average, eight each month. As there are a number of common flaws present in many of these studies, we felt it would be helpful to publish some broad guidance on the subject. While Thorax will always be keen to receive high quality manuscripts dealing with genetic studies in . . . [Full text of this article]

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Comments on Thorax guide to assess the validity of genetic association studies

Ahmed E Hegab, et al.

Thorax Online, 2 Jun 2005 [Full text]