© 2005 BMJ Publishing Group Ltd & British Thoracic Society
LUNG ALERT
Evidence for a genetic susceptibility to lung carcinoma
Clinical Research Fellow, Scottish Pulmonary Vascular Unit, Western Infirmary, Glasgow, UK; ccarlin@tiscali.co.uk
| The first 150 words of the full text of this article appear below. |
Jonsson S, Thorsteinsdottir U, Gudbjartsson DF, et al. Familial risk of lung carcinoma in the Icelandic population. JAMA 2004;292:2977–83
Previous studies of the genetic epidemiology of lung cancer have suggested a modest (twofold) increased risk associated with a family history of lung cancer. It has been unclear whether the increased risk observed reflected genetic factors specific to lung cancer, genetic modifiers of nicotine addiction (leading to increased tobacco exposure), or shared environmental factors.
Jonsson and colleagues accessed the Icelandic genealogical database (which has population and ancestry data for all Icelanders), the Icelandic Cancer Registry (to identify cases of lung cancer), and the Reykjavik Heart Study (which provided smoking information for a cohort of the studied patients). They found a significant (2–3.5 fold) increased risk of developing lung carcinoma in first degree relatives of patients with lung cancer. This relative risk exceeded the relative risk
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