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Thorax 2005;60:263
© 2005 BMJ Publishing Group Ltd & British Thoracic Society

Airwaves

Wisia Wedzicha, Editor in Chief

The first 150 words of the full text of this article appear below.


COPD EXACERBATIONS: OXIDATIVE STRESS AND INFLAMMATION
Exacerbations have become an important target for prevention in the management of COPD as they are associated with impaired health status and disease progression. During COPD exacerbations there is increased airway inflammation, so it is important to study the nature of this inflammation if novel treatments are to be developed. In this issue of Thorax Drost and colleagues report a study of markers of airway inflammation and oxidative stress in patients with severe exacerbations requiring hospital admission and very severe exacerbations requiring intubation and ventilation. Proximal samples were taken together with BAL fluid and some biopsy specimens at bronchoscopy. An influx of inflammatory cells was seen in the peripheral airways at exacerbations with increased interleukin (IL)-8 levels only in the proximal airways. There was evidence of increased oxidative stress at COPD exacerbation with a reduction in glutathione (GSH) levels which was greater with increasing severity of the exacerbation. The data . . . [Full text of this article]


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