© 2005 BMJ Publishing Group Ltd & British Thoracic Society
Airwaves
| The first 150 words of the full text of this article appear below. |
Exacerbations have become an important target for prevention in the management of COPD as they are associated with impaired health status and disease progression. During COPD exacerbations there is increased airway inflammation, so it is important to study the nature of this inflammation if novel treatments are to be developed. In this issue of Thorax Drost and colleagues report a study of markers of airway inflammation and oxidative stress in patients with severe exacerbations requiring hospital admission and very severe exacerbations requiring intubation and ventilation. Proximal samples were taken together with BAL fluid and some biopsy specimens at bronchoscopy. An influx of inflammatory cells was seen in the peripheral airways at exacerbations with increased interleukin (IL)-8 levels only in the proximal airways. There was evidence of increased oxidative stress at COPD exacerbation with a reduction in glutathione (GSH) levels which was greater with increasing severity of the exacerbation. The data
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Articles
- Is big beautiful? The continuing story of ADAM33 and asthma
- S T Holgate and J W Holloway
Thorax 2005 60: 263-264.[Extract] [Full Text] [PDF]
- Contribution of ADAM33 polymorphisms to the population risk of asthma
- J Blakey, E Halapi, U S Bjornsdottir, A Wheatley, S Kristinsson, R Upmanyu, K Stefansson, H Hakonarson, and I P Hall
Thorax 2005 60: 274-276.[Abstract] [Full Text] [PDF]
- Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma
- J E M Tomlinson, A D McMahon, R Chaudhuri, J M Thompson, S F Wood, and N C Thomson
Thorax 2005 60: 282-287.[Abstract] [Full Text] [PDF]
- Oxidative stress and airway inflammation in severe exacerbations of COPD
- E M Drost, K M Skwarski, J Sauleda, N Soler, J Roca, A Agusti, and W MacNee
Thorax 2005 60: 293-300.[Abstract] [Full Text] [PDF]
- Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype
- J Yarden, D Radojkovic, K De Boeck, M Macek, Jr, D Zemkova, V Vavrova, R Vlietinck, J-J Cassiman, and H Cuppens
Thorax 2005 60: 320-325.[Abstract] [Full Text] [PDF]
- Respiratory symptoms in older people and their association with mortality
- J Hewitt, L Smeeth, C J Bulpitt, A J Tulloch, and A E Fletcher
Thorax 2005 60: 331-334.[Abstract] [Full Text] [PDF]
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
