© 2005 BMJ Publishing Group Ltd & British Thoracic Society
EDITORIAL
Angiogenesis and VEGF in COPD
Angiogenesis and vascular endothelial growth factor in COPD
Division of Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
Correspondence to:
Correspondence to:
Professor A J Knox
Division of Respiratory Medicine, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK; alan.knox@nottingham.ac.uk
A possible role for VEGF in the pathology of asthma and COPD
Keywords: chronic obstructive pulmonary disease; asthma; vascular endothelial growth factor; angiogenesis
| The first 150 words of the full text of this article appear below. |
It has been recognised for several hundred years that the bronchial vasculature is an extensive one with early descriptions by Ruysch and possibly Da Vinci.1 However, its function and regulation in health and in disease remain poorly understood. Studies a number of years ago suggested an increased number of bronchial vessels in asthma where increased collagen IV staining, a marker of new vessels, was seen in bronchial biopsies of asthmatic airways compared with controls.2 Subsequent studies by the same group and by Salvato and colleagues have confirmed the presence of angiogenesis in the bronchial circulation in asthma.3,4 There are a number of candidate angiogenic factors for these changes, perhaps the most important of which are vascular endothelial growth factor (VEGF) and the angiopoietins which are distinct molecules that act together at different stages of angiogenic processes in several biological systems.5,6,7,8,9,10,11 Other molecules with angiogenic potential
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