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Cystic lung lesions as an immune reconstitution inflammatory syndrome (IRIS) in HIV-TB co-infection?

D Richardson¹, L Rubinstein¹, E Ross², A Rice³, A R Wright⁴, O M Kon⁵, J Walsh⁶

¹ Department of HIV Medicine, Jefferiss Wing, St Mary’s Hospital, London, UK
² Department of Chest Medicine, The Chest and Allergy Clinic, St Mary’s Hospital, London, UK
³ Department of Histopathology, St Mary’s Hospital, London, UK
⁴ Department of Clinical Radiology St Mary’s Hospital, London, UK
⁵ Department of Chest Medicine, The Chest and Allergy Clinic, St Mary’s Hospital, London, UK
⁶ Department of HIV Medicine, Jefferiss Wing, St Mary’s Hospital, London, UK

Correspondence to:
Correspondence to:
Dr D Richardson
Jefferiss Wing, St Mary’s Hospital, London W2 1NY, UK; daniel.richardson@st-marys.nhs.uk

Keywords: pulmonary cysts; HIV; tuberculosis; immune reconstitution inflammatory syndrome (IRIS)

The first 150 words of the full text of this article appear below.

A 33 year old man presented with a 3 week history of night sweats, fever, productive cough, and intermittent headaches. He was found to be HIV antibody positive and fully sensitive Mycobacterium tuberculosis was cultured from his cerebrospinal fluid, blood, and bronchoalveolar lavage fluid. He did not have Pneumocystisjiroveci. A thin section CT scan of his chest confirmed extensive bilateral cavitation at the apices, multiple small intrathoracic nodules, and moderate mediastinal lymphadenopathy.

Standard antituberculous treatment was commenced and he improved clinically. Four weeks later anti-HIV treatment was introduced. He became febrile again and his clinical status deteriorated with fevers up to 40°C, weight loss, and increased acute phase responses.

A repeat high resolution CT (HRCT) scan revealed new multiple pulmonary cystic lesions together with the thoracic nodules and a small right pneumothorax (fig 1). A wedge biopsy of his lung showed cysts lined by endothelium with a . . . [Full text of this article]

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This article has been cited by other articles:

• Price, P., Murdoch, D. M., Agarwal, U., Lewin, S. R., Elliott, J. H., French, M. A. (2009). Immune Restoration Diseases Reflect Diverse Immunopathological Mechanisms. Clin. Microbiol. Rev. 22: 651-663 [Abstract] [Full Text]  

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