EDITORIAL
Hypoxaemia and COPD
Hypoxaemia enhanced peripheral muscle oxidative stress in COPD
Correspondence to:
Correspondence to:
Dr M Flück
Department of Anatomy, Unit for Functional Anatomy, University of Berne, Baltzerstrasse 2, 3000 Berne 9, Switzerland; flueck@ana.unibe.ch
New findings on the biological defects underlying oxidative damage in patients with COPD
Keywords: chronic obstructive pulmonary disease; exercise; hypoxaemia; lipid peroxidation; lipofuscin; oxidised protein; inflammation
| The first 150 words of the full text of this article appear below. |
Chronic bronchitis and pulmonary emphysema, also know as chronic obstructive pulmonary disease (COPD), is the only leading cause of death with a rising prevalence.1 Typically, the reduced lung function of COPD patients is associated with a general deconditioning of muscle function and the consequent development of a sedentary lifestyle.2 There is clear evidence that pulmonary rehabilitation programmes that involve generic physical exercise training can improve exercise capacity and state of health in patients with COPD,3 so outpatient and home based exercise training are part of the rehabilitation programme for these subjects in Western countries.4
The role of co-factors such as hypoxia and inflammation on the health of COPD patients and the resulting improvements of exercise performance with training are poorly understood, but the paper by Koechlin and colleagues5 in this issue of Thorax shows that exercise performance and peripheral muscle defects in patients with COPD relate to
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