© 2005 BMJ Publishing Group Ltd & British Thoracic Society
EDITORIAL
Chemistry of exhaled nitrogen oxides
Informative complexity of exhaled nitrogen oxide chemistry
Correspondence to:
Correspondence to:
Dr J Hunt
Division of Pediatric Respiratory Medicine, Box 800386, University of Virginia, Charlottesville, VA 22908, USA; jfh2m@virginia.edu
Seeking the meaning of exhaled NO
Keywords: asthma; cystic fibrosis; exhaled breath condensate; nitric oxide; nitrogen oxides; inflammation
| The first 150 words of the full text of this article appear below. |
In this issue of Thorax, Ojoo et al1 conclude their paper with a sentence that is worthy of direct quotation. Their data "draw attention to the complexity of NO [nitric oxide] metabolism, where multiple pathways of NO synthesis and clearance are likely to have variable relevance in different circumstances". Exhaled NO measurement is now a clinically approved test and, with approximately 1000 articles so far published, there are sufficient data to support its utility as an objectively measurable biomarker relevant to lung disease. However, despite all of the publications, how the multiple intracorporeal biochemical pathways interact and determine NO exhalation remains unclear.
In order to avert confusion, it is necessary to assure that vocabulary is shared. "Exhaled NO" has become the vernacular for the fractional exhalation of NO (FENO). This is not the amount of NO produced in the lung. Indeed, only a
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This article has been cited by other articles:
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(2006). ATS Workshop Proceedings: Exhaled Nitric Oxide and Nitric Oxide Oxidative Metabolism in Exhaled Breath Condensate.. Proc Am Thorac Soc
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Horvath, I., Hunt, J., Barnes, P. J., On behalf of the ATS/ERS Task Force on Exhaled Bre,
(2005). Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J
26: 523-548
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