© 2005 BMJ Publishing Group Ltd & British Thoracic Society
LUNG ALERT
SV40 as a causative agent in mesothelioma: a new twist to the story
Wellcome Advanced Fellow, University College London and Honorary Chest Physician, Osler Chest Unit, Oxford, UK; ycgarylee@hotmail.com
| The first 150 words of the full text of this article appear below. |
Lopez-Rios F, Illei PB, Rusch V, Ladanyi M. Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids. Lancet 2004;364:1157–66[CrossRef][Medline]
The potential causal role of simian virus 40 (SV40) in tumourigenesis is the most contentious issue in mesothelioma research of recent years. SV40 is a potent tumour virus and can induce mesothelioma in experimental animals. However, clinical evidence linking SV40 with mesothelioma remains inconclusive. SV40 has been reported in human mesothelioma tissues in many, but not all, previous publications. Although the criteria for causality have not been satisfied, strategies targeting SV40 are already being pursued in clinical trials for mesothelioma.
Lopez-Rios et al used several lines of approach to show that PCR primers used to detect SV40 in many other studies were targeting sequences within the SV40
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