- Extensive pseudomembranous invasive tracheobronchial aspergillosis can be successfully treated in non-severely immunocompromised patients.
Thorax 2004;59:452; doi:10.1136/thx.2004.022046
Copyright © 2004 BMJ Publishing Group Ltd & British Thoracic Society.
Thorax 2004;59:452
© 2004 BMJ Publishing Group Ltd & British Thoracic Society
© 2004 BMJ Publishing Group Ltd & British Thoracic Society
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Pseudomembranous invasive tracheobronchial aspergillosis
Servicio de Neumología, Hospital Clínico Universitario, Valencia, Spain
Correspondence to:
Correspondence to:
Dr J Franco
Servicio de Neumología, Hospital Clínico Universitario, Avda Vicente Blasco Ibáñez 17, 46010 Valencia, Spain; jfs01v@nacom.es
| The first 150 words of the full text of this article appear below. |
Invasive aspergillus tracheobronchitis is a rare infectious complication in severely immunocompromised patients who are generally neutropenic with haematological diseases, AIDS, or after solid organ transplantation. However, a few cases have been reported with no apparent severe compromise in the host defences.1 Aspergillus tracheobronchitis varies from localised tracheobronchitis discovered incidentally at necropsy to more or less extensive bronchial obstruction contributing to respiratory failure. The pseudomembranous form is the most severe condition and is usually fatal despite treatment with antifungal agents.2 However, in non-severely immunocompromised patients the condition can be successfully treated, even in the presence of extensive tracheobronchial involvement.
Learning point
A 70 year old man presented with a history of insulin dependent diabetes mellitus, chronic obstructive pulmonary disease, and old tuberculosis. The possible risk factors included broad spectrum antibiotics and corticosteroids. Fibreoptic bronchoscopy (fig 1A
) revealed
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