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The eosinophil in airway remodelling and hyperresponsiveness in asthma: participant or bystander?
Respirology Resident, McMaster University, Hamilton, Canada; msoth@idirect.com
| The first 150 words of the full text of this article appear below. |
Lee JJ, Dimina D, Macias MP, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004;305:1773–6
Humbles AA, Lloyd CM, McMillan SJ, et al. A critical role for eosinophils in allergic airways remodelling. Science 2004;305:1776–9
While the presence of eosinophils in asthma has long been recognised, it remains unclear whether they are directly involved in the pathogenesis of asthma or are merely an epiphenomenon. Both Lee et al and Humbles et al used an acute inhaled allergen challenge with ovalbumin as a model of asthma. Lee et al used mice that expressed diphtheria toxin A in eosinophils (PHIL mice) resulting in eosinophil apoptosis while Humble et al used mice with mutations in a transcription factor (GATA-1 mice) that selectively prevented the differentiation of myeloid cells into eosinophils. Both mutants were essentially devoid of
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