© 2004 BMJ Publishing Group Ltd & British Thoracic Society
EDITORIAL
Detecting early lung disease in CF
Detecting early lung disease in cystic fibrosis: are current techniques sufficient?
TVW Telethon Institute for Child Health Research, Subiaco, Western Australia 6008, Australia
Correspondence to:
Correspondence to:
Professor P D Sly
TVW Telethon Institute for Child Health Research, Subiaco, Western Australia 6008, Australia; peters@ichr.uwa.edu.au
Use of the multiple breath inert gas washout technique in the early diagnosis of CF
Keywords: cystic fibrosis; children; multiple breath washout; spirometry
| The first 150 words of the full text of this article appear below. |
The philosophy underlying treatment at most cystic fibrosis (CF) clinics is essentially preventative—that is, early detection, treatment and hopefully resolutions of problems before they become major clinical issues. The introduction of newborn screening programmes around the world is also based on the idea that early detection and treatment will result in an improved outcome for patients. Progressive lung disease represents the greatest threat to the health and well being of patients with CF. The goal of treatment is to prevent or delay progressive lung disease, so early detection and monitoring of effective treatments would be expected to improve the health and life expectancy of children with CF.
Lung disease in CF is characterised by a progression from bacterial colonisation to mucosal infection and finally invasive infection. This is accompanied by a host inflammatory response characterised by cytokine secretion and influx of neutrophils. The neutrophils
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