© 2004 BMJ Publishing Group Ltd & British Thoracic Society
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Sildenafil and exercise capacity in hypoxic pulmonary hypertension
The Cleveland Clinic Foundation, Cleveland, Ohio, USA; mughalm@ccf.org
| The first 150 words of the full text of this article appear below. |
Ghofrani HA, Reichenberger F, Kohstall MG, et al. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp. Ann Intern Med 2004;141:169–77
This study examined the influence of oral sildenafil on pulmonary haemodynamics and exercise tolerance during hypoxia induced pulmonary hypertension in healthy mountaineers and trekkers who were not susceptible to high altitude pulmonary oedema. Fourteen healthy volunteers (12 men, median age 36.5 years) were enrolled and randomised in a double blind, placebo controlled, crossover design. Participants were assigned to receive placebo or one 50 mg dose of sildenafil. Systolic pulmonary artery pressure, cardiac output, and peripheral arterial oxygen saturation at rest and during assessment of maximum exercise capacity on cycle ergometry were measured, both while breathing a hypoxic gas mixture with 10% fraction of inspired oxygen at low altitude and then at the Mount Everest base camp (5400
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