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Contamination of rhinovirus stocks with poliovirus type 1
St Bartholomew’s Hospital, London, UK tomw1970@hotmail.com
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Davies M, Bruce C, Bewley K, et al. Poliovirus type 1 in working stocks of typed human rhinoviruses. Lancet 2003;361:1187–8[CrossRef][Medline]
Savolainen C, Hovi T. Caveat: poliovirus may be hiding under other labels. Lancet 2003;361:1145–6[CrossRef][Medline]
One of the major successes of public health vaccination programmes has been the eradication of circulating poliovirus from the majority of countries in the world. Reintroduction of wild type poliovirus may occur following spread from sources of virus stored in virological and other laboratories for research purposes or from countries where polio remains endemic. It is therefore of obvious concern that the authors at the National Collection of Pathogenic Viruses (NCPV), whilst characterising stocks of rhinovirus from the MRC Common Cold Research Unit, found that five of 22 cell cultures had abnormal cytopathic effects when infected with putative rhinovirus. PCR and sequencing confirmed that four of these putative rhinovirus
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