© 2003 BMJ Publishing Group & British Thoracic Society
LETTER TO THE EDITOR
Sleep disordered breathing in an adult with cherubism
Department of Respiratory Medicine, T N Medical College and B Y L Nair Hospital, Mumbai, India
Correspondence to:
Correspondence to:
Dr J M Joshi, Department of Respiratory Medicine, T N Medical College and B Y L Nair Hospital, Mumbai-400008, India;
deptrespmed@hathway.com
Keywords: cherubism; obstructive sleep apnoea
| The first 150 words of the full text of this article appear below. |
Cherubism is a rare disorder with bilateral enlargement of the mandible that regresses with time. Bone degrading osteoclasts and bone building osteoblasts function abnormally causing the changes. It is an autosomal dominant condition which manifests in early childhood by the age of 2–5 years, but later regresses with time. Airway obstruction occurs due to backward displacement of the tongue affecting respiration.
An 18 year old male was referred to us for snoring. On inquiry the mother reported swelling of the lower face since childhood, which had progressed to its present size. The patient had difficulty in speech, mastication, and swallowing with mental retardation. There was a history of excessive daytime somnolence, nocturia, and increased irritability during the previous few years. On examination he had characteristic features of cherubism. The lower eyelids were retracted and his oral examination revealed gingival hypertrophy with most of the upper and lower teeth embedded in
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