© 2002 Thorax
EDITORIAL
Gene expression profiling
Gene expression profiling: good housekeeping and a clean message
Correspondence to:
Correspondence to:
Dr R C Chambers, Centre for Respiratory Research, University College London, London WC1E 6JJ, UK;
R.Chambers@ucl.ac.uk
Microarray technology offers us the means of monitoring gene expression on a scale which was hard to envisage only a few years ago.
Keywords: gene expression; microarray technology
| The first 150 words of the full text of this article appear below. |
There is no doubt that gene expression studies based on evaluating mRNA levels for single or multiple genes of interest in human lung biopsy tissue have had a major impact on our understanding of the molecular mechanisms underlying respiratory disease. The recent advent of microarray technology has added further impetus to the central paradigm that mRNA quantification in lung tissue can shed light on pathogenesis and identify new targets for therapeutic intervention. This technology is now so advanced that it allows the parallel monitoring of entire genomes using microarrays with a surface area equivalent to just a few square centimetres and as little as 5 µg RNA starting material.
Since its first application in the mid 1990s,1 microarray technology has been applied to all aspects of biomedical research with over 60 papers in respiratory research alone. It has been successfully used for the classification and molecular diagnosis
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