Review series
Respiratory diseases in pregnancy
4
Women with cystic fibrosis and their potential for reproduction
F P EdenboroughAdult Cystic
Fibrosis Unit, Northern General Hospital, Herries Road, Sheffield
S5 7AU, UK
Correspondence to: Dr F P Edenborough f.edenborough@yahoo.com
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
While it has long been appreciated that up to 98% of men with
cystic fibrosis (CF) are infertile due to a failure to develop, or
early blockage of, the mesonephric ducts and vas
deferens,1 the effect of CF on the fertility of women is
less clear. Survival is now into the fourth decade of life and, with
the largest growth in the CF population seen in the adult age
groups,2 it is not surprising that the issues of fertility
and reproduction are increasingly raised in adult clinics. Pregnancy is
possible and increasing numbers of children are born to women with CF
each year.3 Since the first pregnancy in
1960,4 management of all aspects of CF has improved and so
the prognosis for mother and child has also improved. This paper
reviews the pathophysiology of CF in the female reproductive tract, its
effect on fertility and the ability to carry a
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