Thorax 2001;56:317-323 ( April )

Review series

Paediatric origins of adult lung disease  8

Long term sequelae of bronchopulmonary dysplasia (chronic lung disease of infancy)

E Eber, M S Zach

Respiratory and Allergic Disease Division, Paediatric Department, University of Graz, Austria

Correspondence to: Univ-Prof Dr E Eber, Klinische Abteilung für Pulmonologie/Allergologie, Univ-Klinik für Kinder- und Jugendheilkunde, Auenbruggerplatz 30, A-8036 Graz, Austria ernst.eber@kfunigraz.ac.at

The first 150 words of the full text of this article appear below.

	Introduction

Bronchopulmonary dysplasia (BPD) is the most common form of chronic lung disease in infancy. The clinical, radiological, and pathological features of BPD were first described a little more than three decades ago.¹ The disease was then seen in large preterm infants with severe respiratory distress syndrome who had been treated with high inspired oxygen concentrations and prolonged mechanical ventilation with high positive airway pressures resulting in inflammation, fibrosis, and smooth muscle hypertrophy in the airways.² Despite advances in the prevention and management of respiratory distress syndrome (including the widespread use of antenatal steroids and surfactant treatment), neonatal chronic lung disease is still one of the major complications in mechanically ventilated premature infants. Acceptance of modest hypercapnia with less aggressive application of positive pressure ventilation and reduction of the use of high oxygen concentrations led to a decrease in the incidence of BPD in newborn infants with a birth weight above . . . [Full text of this article]

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