Thorax 2000;55:587-594 ( July )

Review series

Paediatric origins of adult lung disease  1

The contribution of airway development to paediatric and adult lung disease

Stephen Stick

Department of Respiratory Medicine, Princess Margaret Hospital for Children and TVW Institute for Child Health Research, Perth, Western Australia

Correspondence to: Dr S Stick email: stephen.stick@health.wa.gov.au

The first 150 words of the full text of this article appear below.

	Introduction

Airway development is only one of the factors that is important in the pathogenesis of complex respiratory disorders such as asthma and chronic airflow limitation. For example, knowledge of the interactions between the developing lung, genetic, environmental, and immunological factors is essential if progress is to be made in early diagnosis and the development of new interventions aimed at reducing the long term morbidity from chronic lung diseases. However, such a review is beyond the scope of this article which is limited to the role of airway development during childhood in determining adult lung function and the outcome of chronic airway disease. Some childhood respiratory diseases such as cystic fibrosis and various congenital lung disorders have obvious sequelae or adverse outcomes in adults. However, these conditions are relatively rare compared with chronic airflow limitation and asthma, the major symptomatic manifestations in adults of airway abnormalities. Most studies that have examined . . . [Full text of this article]

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