Thorax 1999;54:287-288 ( April )

Editorial

EUROSCOP, ISOLDE and the Copenhagen City Lung Study

The first 150 words of the full text of this article appear below.

In some countries inhaled corticosteroids are widely prescribed for patients with chronic obstructive pulmonary disease (COPD), despite the lack of good studies to support their use. In the last 12 months these three important large, parallel group, placebo controlled studies have reported at scientific meetings but, at the time of going to press with this article, they have not been published. This review will give an individual view of what has been presented, and provide a basis for the assessment of the trials when they are published.

All three studies used similar definitions of COPD and excluded patients with a clinical diagnosis of asthma or significant bronchodilator responsiveness. The Copenhagen study also excluded those with a prednisolone response, which was found in only 5% of their otherwise unselected population. The Copenhagen study started with a random population survey which identified all those with an FEV₁/VC ratio of <70%, irrespective of . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Pistolesi, M. (2009). Beyond airflow limitation: another look at COPD. Thorax 64: 2-4 [Full Text]  
• Bourbeau, J., Ford, G., Zackon, H., Pinsky, N., Lee, J., Ruberto, G. (2007). Impact on patients' health status following early identification of a COPD exacerbation. Eur Respir J 30: 907-913 [Abstract] [Full Text]  
• Leigh, R., Pizzichini, M. M. M., Morris, M. M., Maltais, F., Hargreave, F. E., Pizzichini, E. (2006). Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment. Eur Respir J 27: 964-971 [Abstract] [Full Text]  
• Garcia-Aymerich, J, Farrero, E, Felez, M A, Izquierdo, J, Marrades, R M, Anto, J M (2003). Risk factors of readmission to hospital for a COPD exacerbation: a prospective study. Thorax 58: 100-105 [Abstract] [Full Text]  
• Toward, T. J., Broadley, K. J. (2002). Goblet Cell Hyperplasia, Airway Function, and Leukocyte Infiltration after Chronic Lipopolysaccharide Exposure in Conscious Guinea Pigs: Effects of Rolipram and Dexamethasone. J. Pharmacol. Exp. Ther. 302: 814-821 [Abstract] [Full Text]  
• Sturton, G., Fitzgerald, M. (2002). Phosphodiesterase 4 Inhibitors for the Treatment of COPD*. Chest 121 : 192S-196S [Abstract] [Full Text]  
• Toward, T. J., Broadley, K. J. (2001). Chronic Lipopolysaccharide Exposure on Airway Function, Cell Infiltration, and Nitric Oxide Generation in Conscious Guinea Pigs: Effect of Rolipram and Dexamethasone. J. Pharmacol. Exp. Ther. 298: 298-306 [Abstract] [Full Text]  
• Wilson, R. (2001). Bacteria, antibiotics and COPD. Eur Respir J 17: 995-1007 [Abstract] [Full Text]  
• Pauwels, R. (2000). COPD : The Scope of the Problem in Europe. Chest 117 : 332S-335S [Abstract] [Full Text]  
• CALVERLEY, P. M.A. (2000). Inhaled Corticosteroids Are Beneficial in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 161: 341-342 [Full Text]  
• BARNES, P. J. (2000). Inhaled Corticosteroids Are Not Beneficial in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 161: 342-344 [Full Text]  
• CALVERLEY, P. M.A. (2000). REBUTTAL FROM DR. CALVERLEY. Am. J. Respir. Crit. Care Med. 161: 344-344 [Full Text]  
• Pearson, M. G. (2000). How Can the Implementation of Guidelines Be Improved?. Chest 117 : 38S-41S [Abstract] [Full Text]  
• Calverley, P., Bellamy, D. (2000). Issues at the interface between primary and secondary care in the management of common respiratory disease bullet 5: The challenge of providing better care for patients with chronic obstructive pulmonary disease: the poor relation of airways obstruction?. Thorax 55: 78-82 [Full Text]  
• CHENG, T. O (1999). Acronyms. Thorax 54: 750c-750 [Full Text]