Editorial
Vascularity in asthmatic airways: relation to inhaled steroid dose
| The first 150 words of the full text of this article appear below. |
The physiological consequences of altered
airways structure on the function of asthmatic airways has been of
interest to clinicians and physiologists since the classic study of
Huber and Koessler in 1922.1 These authors provided the
first measurements of airway wall thickness in relation to their size
and reported that the airway wall of patients who died of asthma was
thicker than that of controls. Many have subsequently commented on this
finding,2-7 and Freedman provided an excellent review of
its functional significance in 1972.8 A systematic
analysis of the effect of wall thickening on airway function by Moreno
and colleagues showed that a thickening of the inner aspect of the
airway wall that had little or no effect on baseline airways resistance
was capable of amplifying the effect of smooth muscle shortening on
airway calibre to account for the airways hyperresponsiveness of
asthmatic subjects.9 A series of studies followed that
further
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