Editorial
Re-assessing the evidence about inhaled corticosteroids in chronic obstructive pulmonary disease
| The first 150 words of the full text of this article appear below. |
"For now we see through a glass darkly;"
Corinthians I: 13 v.12
Research into chronic obstructive pulmonary disease (COPD), for so long
the Cinderella disorder of respiratory medicine, has undergone
something of a renaissance in the last 10 years, with an increased
awareness of its high prevalence1 as well as its growing
importance as a cause of death in the developing world.2 Having achieved a measure of consensus on the most appropriate definition,3-5 more mechanistic studies have shown that
inflammatory cell infiltration in the walls of large
airways6 and the presence of pro-inflammatory cytokines in
induced sputum are frequent findings in patients with
COPD.7 8 The characteristics of the cellular and
biochemical changes differ from those seen in asthma with a
predominance of alveolar macrophages and a relative neutrophilia, whilst the lymphocytes in the airway wall show no evidence of the CD4+
predominance seen in asthmatic airways.6 Data from a
variety of groups
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