Editorial
Augmentation therapy for severe 
1-antitrypsin
deficiency: is the jury still out on a trial?
| The first 150 words of the full text of this article appear below. |
As with the administration of insulin for diabetes mellitus,
the rationale for administering purified 
1-antiprotease
in severe 1-antitrypsin (1AT)
deficiency
a treatment dubbed "augmentation therapy"is to
provide the substance whose deficiency is deemed responsible for the
pulmonary sequelae of 1AT deficiency. Indeed, even as
intravenous augmentation therapy has been advocated for severely
deficient individuals with established airflow obstruction by some
official societies (but not all),1 2 and even as one
commercial product has been licensed by the United States Federal Drug
Administration with other intravenous and inhaled preparations
currently under investigation, the efficacy of augmentation therapy
continues to be actively debated. As with many controversies in
medicine, this one centres on the nature and adequacy of available supportive evidence versus the gaps in current knowledge. In the wake
of the recently published outcome data from the American National
Heart, Lung, and Blood Institute (NHLBI) sponsored Registry of Patients
with
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Stoller, J K
(2004). {alpha}1-Antitrypsin deficiency. Thorax
59: 92-93
[Full Text] -
Tremblay, G. M., Vachon, E., Larouche, C., Bourbonnais, Y.
(2002). Inhibition of Human Neutrophil Elastase-Induced Acute Lung Injury in Hamsters by Recombinant Human Pre-elafin (Trappin-2). Chest
121: 582-588
[Abstract] [Full Text] -
Stoller, J. K., Brantly, M., Fleming, L. E., Bean, J. A., Walsh, J.
(2000). Formation and Current Results of a Patient-Organized Registry for {alpha}1-Antitrypsin Deficiency. Chest
118: 843-848
[Abstract] [Full Text] -
Stockley, R A
(2000). Alpha-1-antitrypsin deficiency: what next?. Thorax
55: 614-618
[Full Text]
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
